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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Oct 19;191:114583. doi: 10.1016/j.addr.2022.114583

Fig. 5.

Fig. 5.

FUS peak-negative acoustic pressure (PNP) may be tuned to yield sonoselective cerebrovascular endothelial transfection. (A and B) Confocal images of FUS+ (0.1 MPa) and contralateral FUS− brain tissue showing expression of mCherry reporter gene (red) with respect to endothelial cells (BS-I lectin, green). Arrows denote mCherry colocalization with endothelium. (C) Bar graphs of fraction of mCherry expression in cerebrovascular endothelium as a function of PNP. Highly selective endothelial transfection is observed at low PNPs (i.e., 0.1 MPa and 0.2 MPa). One-way ANOVAs followed by Dunnett’s multiple comparisons tests. [140].