Table 2.

Summary of all currently-registered clinical trials of FUS-mediated BBB opening in human patients, separated by disease condition.

Disease / condition	Study ID	No. of patients	Outcome measures	FUS device	Complete?
Alzheimer’s disease	NCT04118764	6	Efficacy of BBBO No. of safety events Change in amyloid uptake Change in cognitive function	Neuronavigation-guided system	No
	NCT04526262	6	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	No
	NCT02986932	6	Efficacy of BBBO Change in amyloid uptake Adverse events Change in cognitive function	ExAblate 4000 Type 2	Yes
	NCT03739905	30	Adverse events Efficacy of BBBO Change in cognitive function Change in amyloid uptake	ExAblate 4000 Type 2	No
	NCT04526262	6	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	Yes
Parkinson’s disease	NCT03608553	10	Adverse events Feasibility of BBBO	ExAblate 4000 Type 2	No
	NCT04370665	4	Efficacy of BBBO Adverse events Efficacy of Cerezyme delivery	ExAblate 4000 Type 2	No
Brain tumors	NCT02343991	10	Adverse events	ExAblate 4000 Type 2	Yes
	NCT03551249	20	Adverse events Feasibility of repeated BBBO	ExAblate 4000 Type 2	No
	NCT04063514	15	Adverse events Functional magnetic resonance imaging	DWL or Brainsonix	No
	NCT04804709	3	Adverse events Survival Efficacy of BBBO	Neuronavigation-guided system	No
	NCT03616860	20	Adverse events Feasibility of repeated BBBO Efficacy of BBBO	ExAblate 4000 Type 2	No
	NCT04998864	5	Adverse events Feasibility of repeated BBBO	ExAblate 4000 Type 2	No
	NCT03714243	10	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	No
	NCT04440358	50	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	No
	NCT04417088	30	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	No
	NCT03712293	10	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	No
	NCT03626896	6	Adverse events Dose limiting toxicity Efficacy of BBBO	NaviFUS	Yes
	NCT04446416	10	Adverse events Survival Clinical response Efficacy of BBBO	NaviFUS	No
	NCT03744026	33	Dose limiting toxicity Efficacy of BBBO	SonoCloud-9	Yes
Amyotrophic lateral sclerosis	NCT03321487	8	Adverse events Efficacy of BBBO	ExAblate 4000 Type 2	Yes