Table 3.
Neuritic plaque pathology in Lewy pathology GBS subgroups of the two datasets.
| Global Lewy pathology Burden Score (GBS) | |||||
|---|---|---|---|---|---|
| 1–10 | 11–20 | 21–30 | 31+ | ||
| CERAD | Vantaa dataset | ||||
| Amygdala | 0-A (n) | 1 | 0 | 0 | 0 |
| B-C (n) | 9 | 11 | 9 | 9 | |
| Total (n) | 10 | 11 | 9 | 9 | |
| Brainstem/PNS | 0-A (n) | 8 | 10 | 6 | 6 |
| B-C (n) | 8 | 6 | 11 | 18 | |
| Total (n) | 16 | 16 | 17 | 24 | |
| All Vantaa cases | 0-A (n) | 9 | 10 | 6 | 6 |
| B-C (n) | 17 | 17 | 20 | 27 | |
| Total (n) | 26 | 27 | 26 | 33 | |
| CERAD | Tokyo dataset | ||||
| Amygdala | 0-A (n) | 11 | 7 | 7 | 13 |
| B-C (n) | 13 | 8 | 7 | 24 | |
| Total (n) | 24 | 15 | 14 | 37 | |
| Brainstem/PNS | 0-A (n) | 25 | 10 | 8 | 0 |
| B-C (n) | 5 | 3 | 4 | 1 | |
| Total (n) | 30 | 13 | 12 | 1 | |
| All Tokyo cases | 0-A (n) | 36 | 17 | 15 | 13 |
| B-C (n) | 18 | 11 | 11 | 25 | |
| Total (n) | 54 | 28 | 26 | 38 | |
Global Burden Scores (GBS) signify the summed burden of Lewy pathology. The amygdala- and brainstem/PNS-predominant cases in both datasets are divided into GBS categories of global mild (1–10), moderate (11–20), severe (21–30), and very severe (31+) Lewy pathology. In each subgroup, the number of cases (n) with CERAD stage 0-A (none, mild) and B-C (moderate, severe) is listed. Note that the table does not contain the full samples from the two datasets, since 12 (10%) Vantaa cases and 32 (18%) Tokyo cases could not be unequivocally assigned to amygdala-predominant or brainstem/PNS-predominant categories, since they had equal amounts of pathology in the AMY + TOX and DMV + sympathetic structures used for categorization of cases.