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. 2022 Nov 21;36(12):1269–1283. doi: 10.1007/s40263-022-00963-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Mean (95% CI) off-time reduction (h/day) with the three device-aided therapies versus best medical treatment. The analysis adjusted for baseline age, sex, disease duration, levodopa daily dose, and off-time. BMT best medical therapy, CSAI continuous subcutaneous apomorphine infusion, DBS deep brain stimulation, LCIG levodopa/carbidopa intestinal gel