. 2022 Nov 21;36(12):1269–1283. doi: 10.1007/s40263-022-00963-9

Table 3.

Summary of off-time changes from the ten studies that reported off-time at 6 months

Author/Reference	Trial interventions	Baseline off-time in h/day, mean (SD)^a	Reduction in off-time at 6 months in h/day, mean (SD)
Antonini et al. (2017) [25]	LCIG	5.9 (3.1)	4.2 (3.2)
Fernandez et al. (2015) [23]	LCIG	6.8 (2.4)	4.3 (3.2)
Olanow et al. (2014) [11]	LCIG	6.3 (1.7)	3.3 (3.1)^b
Olanow et al. (2014) [11]	BMT	6.9 (2.1)	2.0 (2.3)^b
Borgemeester and van Laar (2017) [33]	CSAI	NR	1.7 (3.6)
De Fabregues et al. (2017) [36]	LCIG	6.0 (1.4)	4.9 (1.1)^b
Katzenschlager et al. (2018) [12]	CSAI	6.7 (2.2)	2.5 (3.7)^b
Katzenschlager et al. (2018) [12]	BMT	6.7 (2.5)	0.6 (2.8)^b
Li et al. (2017) [42]	DBS	8.7 (2.9)	4.4 (4.7)^b
Murata et al. (2016) [44]	LCIG	7.4 (2.3)	4.6 (3.0)^b
Timmermann et al. (2015) [46]	DBS	5.4 (3.1)	3.2 (3.9)
Weaver et al. (2009) [13]	DBS	5.9 (2.6)	2.4 (3.7)
Weaver et al. (2009) [13]	BMT	5.6 (2.9)	0.0 (1.5)

BMT best medical treatment, CSAI continuous subcutaneous apomorphine infusion, DBS deep brain stimulation, LCIG levodopa/carbidopa intestinal gel, NR not reported, SD standard deviation

^aMeasured by patient diary except Antonini et al. (2017)

^bData at 3 months carried forward