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. 2022 Nov 30;12:20662. doi: 10.1038/s41598-022-25373-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Amino acid substitutions in SARS-CoV-2 genomes from Alaska. Scatterplots depicting the (A) total AA substitutions over time. Data includes each genome from an Alaskan confirmed case, colored by variant. The lines show a generalized linear model regression of not emerging lineage cases before 2021-04-04 (gray), after 2021-04-04 (black), Alpha (yellow), and B.1.1.519 (red). (B) Boxplot of number of S protein AA substitutions per genome from sequences pre-peak prevalence of B.1.1.519 on 2021–04-04, B.1.1.519, and post peak prevalence genomes. Diamonds depict the mean number of AA substitutions. Points are individual genomes colored by lineage. Wilcoxon test between group significance p < 0.0001 ****, p < 0.05 *, ns > 0.1.