Fig. 1.

Impact of comorbidities on the overall survival of CML patients. The causes of death as reported in references 14–19 were examined. These studies included patients treated with various TKIs. A The bar chart shows that the cause of death in CML patients in these studies was mainly associated with reasons other than CML. B The pie chart illustrates the breakdown of the CML-unrelated causes of death. CML-related death, which resulted from CML progression or due to transplant complications, accounted for a quarter of the causes of death. Other causes of death included sepsis, terminal kidney insufficiency, cerebral bleeding, and pneumonia. Cardiovascular diseases encompassed cardiac insufficiency, myocardial infarction, cerebral stroke, and cardiac arrhythmias. Secondary tumors comprised prostate, colon, breast, lung, and bladder cancers