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. 2022 Nov 30;13:7371. doi: 10.1038/s41467-022-35241-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Representative slit lamp photographs of untreated, vehicle-, and SSOE-treated eyes up to 28 days after burn using broad beam lighting (a) and slit beam lighting (b). c Progressive worsening of optical opacity in untreated and vehicle-treated eyes after burn, while SSOE-treated eyes maintained optical clarity. Data are presented as mean ± SEM. P = 0.1537 at day 1 timepoint, ***P = 0.0004, ****P < 0.0001. Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparisons test (two-sided). d At day 7 after burn, over 80% of eyes in untreated and vehicle-treated groups developed visually significant cataract, compared to less than 20% in SSOE group. Statistical significance was determined using Fisher’s exact test. e Corneal neovascularization (CNV) score and centricity (f, length of longest blood vessel from limbus) were comparable among all three groups. Data are presented as mean ± SEM. Days 1 and 2: n = 20, 25, 23 eyes in untreated, vehicle and SSOE-treated groups, respectively; days 5 and 7: n = 18, 25, 21 eyes in untreated, vehicle and SSOE-treated groups, respectively; day 10: n = 9, 10, 11 eyes in untreated, vehicle and SSOE-treated groups, respectively; day 14: n = 11, 17, 13 eyes in untreated, vehicle and SSOE-treated groups, respectively; days 21 and 28: n = 7, 13, 9 eyes in untreated, vehicle and SSOE-treated groups, respectively. There is no significance in CNV and centricity among untreated, vehicle and SSOE-treated groups (P > 0.05). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparisons test (two-sided). Data were summarized from seven independent experiments. Source data are provided as a Source Data file.