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. 2022 Nov 30;13:7361. doi: 10.1038/s41467-022-35022-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a CLSM images of intracellular localization of FITC-labelled NMPNs and FITC-labelled PNPs after incubated for 6 h under different pH conditions. Scale bar: 20 μm. Arrows indicate NMPNs in the cytoplasm after the escape from endosomes in cisplatin-resistant Huh7 cells. b CLSM images of intracellular localization of FITC-labelled NMPNs and FITC-labelled PNPs after incubated for 12 h under different pH conditions. Scale bar: 40 μm. Asterisks indicate NMPNs in the nucleus of cisplatin-resistant Huh7 cells. c Quantitative analysis of the colocalization between lysotracker and FITC-labelled NMPNs or PNPs. d Quantitative analysis of the colocalization between DAPI and FITC-labelled NMPNs or PNPs. e Bio-TEM images of cells after incubation for 12 h with NMPNs under different pH conditions. Arrowheads indicate NMPNs accumulated in the nucleus of Huh7 cells. Black asterisks indicate NMPNs in nucleus. Scale bar: 1 μm. f Schematic diagram of the NMPNs to target the tumour cell nucleus. All data are presented as means ± SEM, n = 3 independent experiments. Statistical significance was analyzed by one-way ANOVA with multiple comparisons test (c, d). Source data are provided as a Source Data file.