TABLE 7.
Effect size of GGT/HDL-c ratio on non-alcoholic fatty liver disease (NAFLD) in prespecified and exploratory subgroups.
| Characteristic | No. of participants | HR (95% CI) | P-value | P for interaction |
| Age, years | 0.7997 | |||
| < 30 | 2245 | 1.010 (1.003, 1.018) | 0.0071 | |
| 30 to < 40 | 3531 | 1.014 (1.009, 1.019) | < 0.0001 | |
| 40 to < 50 | 2699 | 1.014 (1.008, 1.020) | < 0.0001 | |
| 50 to < 60 | 1576 | 1.014 (1.007, 1.021) | 0.0001 | |
| 60 to < 70 | 826 | 1.007 (0.997, 1.017) | 0.1661 | |
| ≥ 70 | 1014 | 1.013 (1.005, 1.022) | 0.0027 | |
| Gender | 0.0869 | |||
| Male | 6502 | 1.016 (1.012, 1.019) | < 0.0001 | |
| Female | 5389 | 1.012 (1.008, 1.015) | < 0.0001 | |
| BMI (kg/m2) | 0.2277 | |||
| < 18.5 | 946 | 1.001 (0.890, 1.126) | 0.9873 | |
| ≥ 18.5, < 24 | 9368 | 1.018 (1.015, 1.022) | < 0.0001 | |
| ≥ 24 | 1577 | 1.013 (1.008, 1.018) | < 0.0001 | |
| FPG (mmol/L) | 0.0874 | |||
| ≤ 6.1 | 11066 | 1.015 (1.012, 1.018) | < 0.0001 | |
| > 6.1 | 825 | 1.008 (1.000, 1.016) | 0.0409 | |
| TG (mmol/L) | 0.0184 | |||
| < 1.7 | 9404 | 1.018 (1.014, 1.021) | < 0.0001 | |
| ≥ 1.7 | 2487 | 1.012 (1.008, 1.015) | < 0.0001 | |
| ALT (U/L) | 0.1284 | |||
| ≤ 40 | 11308 | 1.015 (1.012, 1.018) | < 0.0001 | |
| > 40 | 583 | 1.010 (1.003, 1.016) | 0.0034 | |
| UA (umol/L) | 0.5161 | |||
| < 420 | 10958 | 1.014 (1.011, 1.017) | < 0.0001 | |
| ≥ 420 | 933 | 1.011 (1.004, 1.018) | 0.0013 | |
| SBP (mmHg) | 0.0521 | |||
| < 140 | 10177 | 1.015 (1.012, 1.018) | < 0.0001 | |
| ≥ 140 | 1714 | 1.010 (1.005, 1.015) < 0.0001 | ||
| DBP (mmHg) | 0.3167 | |||
| < 90 | 10926 | 1.015 (1.012, 1.018) | < 0.0001 | |
| ≥ 90 | 965 | 1.012 (1.006, 1.018) | 0.0002 |
Above model adjusted for we adjusted age, sex, SBP, BMI, DBP, ALT, ALP, ALB, TBIL, GLB, UA, FBG, TG, Scr, and LDL-c. In each case, the model is not adjusted for the stratification variable. HR, Hazard ratios; CI, confidence; Ref, reference; NAFLD, non-alcoholic fatty liver disease.