Table 2.
Detail information of the M2 macrophage-associated hub genes.
| Genes | Description | Function |
|---|---|---|
| AIF1 | allograft inflammatory factor 1 | encodes a protein that binds actin and calcium, promots macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes |
| C1QA | complement C1q A chain | component of the serum complement system |
| C1QB | complement C1q B chain | component of the serum complement system |
| C3AR1 | complement C3a receptor 1 | an orphan G protein-coupled receptor for C3a, activates chemotaxis, granule enzyme release, superoxide anion production and bacterial opsonization |
| CCR1 | C-C motif chemokine receptor 1 | a member of the beta chemokine receptor family, receptor of MIP-1 alpha, RANTES, MCP-3 and MPIF-1 |
| CD163 | CD163 molecule | a member of the scavenger receptor cysteine-rich (SRCR) superfamily, exclusively expressed in monocytes and macrophages |
| CD4 | CD4 molecule | a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules |
| CD53 | CD53 molecule | a member of the transmembrane 4 superfamily, mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility |
| CD86 | CD86 molecule | a type I membrane protein that is a member of the immunoglobulin superfamily, expressed by antigen-presenting cells |
| CSF1R | colony stimulating factor 1 receptor | the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages |
| CYBB | cytochrome b-245 beta chain | composition of cytochrome b, a primary component of the microbicidal oxidase system of phagocytes |
| FCER1G | Fc epsilon receptor Ig | gamma chain of high affinity IgE receptor |
| FCGR3A | Fc gamma receptor IIIa | a receptor for the Fc portion of IgG, involved in the removal of antigen-antibody complexes from the circulation |
| IL10RA | interleukin 10 receptor subunit alpha | a receptor for interleukin 10, mediate the immunosuppressive signal of interleukin 10, inhibits the synthesis of proinflammatory cytokines |
| ITGB2 | integrin subunit beta 2 | combines with multiple different alpha chains to form different integrin heterodimers, integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling |
| LAPTM5 | lysosomal protein transmembrane 5 | a transmembrane receptor that is associated with lysosomes |
| PLEK | pleckstrin | enables phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity |
| TYROBP | transmembrane immune signaling adaptor TYROBP | a transmembrane signaling polypeptide, associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element |