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. 2022 Nov 30;7:384. doi: 10.1038/s41392-022-01254-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Activation of FFAR4 by TUG891 ameliorated cellular senescence in cisplatin-induced AKI mice. a Relative mRNA expression of p53 and p21 in kidney tissues (n = 6; ****P < 0.0001, CP vs. Control; ^####P < 0.0001, CP + TUG891 vs. CP). b Protein expression of p53, p21, and p-Rb/Rb in kidneys was detected by western blotting and quantified by densitometry (n = 6; ****P < 0.0001, ***P < 0.001, CP vs. Control; ^####P < 0.0001, CP + TUG891 vs. CP). c Relative mRNA expression of IL-6, IL-1β, TNF-α, and IL-8 in kidney tissues (n = 6; ****P < 0.0001, CP vs. Control; ^####P < 0.0001, CP + TUG891 vs. CP). d Protein expression of LaminB1, ɣH2A.X, IL-6, and IL-1β in kidneys was detected by western blotting and quantified by densitometry (n = 6; ****P < 0.0001, CP vs. Control; ^####P < 0.0001, CP + TUG891 vs. CP). e Representative images and quantitative analysis of SA-β-gal staining of kidney sections (200×, scale bar = 50 μm; 400×, scale bar = 20 μm; n = 6; ****P < 0.0001). f Immunofluorescence of p21 (red) in proximal tubules (LTL, green) in kidney sections (200×, scale bar = 50 μm). Data are presented as mean ± SD. CP, cisplatin