Fig. 7.

Activation of FFAR4 reversed the decrease of SirT3 in cisplatin-induced AKI. a, c Protein expression of SirT3 in kidney tissues detected by western blotting and quantified by densitometry (n = 6; ****P < 0.0001, *P < 0.05). b, d Protein expression of SirT3 in TCMK-1 cells detected by western blotting and quantified by densitometry (n = 3; ****P < 0.0001, ***P < 0.001, **P < 0.01). e, f The DHE staining of kidney sections (200×, scale bar = 50 μm; 400×, scale bar = 20 μm). g, h The ROS production in TCMK-1 cells was assessed by DCFH-DA staining (100×, scale bar = 250 μm). Data are presented as mean ± SD. CP cisplatin