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. 2022 Nov 30;12:20622. doi: 10.1038/s41598-022-24954-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cumulative in vitro release of dexamethasone (μg/mg Ms) [in green] from Dexamethasone-loaded microspheres [dark green] and Dexamethasone/Fibronectin-loaded microspheres [light green]. Cumulative in vitro release of fibronectin (ng/mg Ms) [in red]. Release media: PBS (pH 7.4 isotonized with NaCl) and 0.02% Na azide. Note: To simulate the in vivo conditions of the animal model obtained by two injections of Dexamethasone-loaded microspheres, a second dose of microspheres was included in the release media at 28 days [black arrow]. DX dexamethasone, FN fibronectin, Ms microspheres.