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. 2022 Nov 30;12:20622. doi: 10.1038/s41598-022-24954-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vitreous parainflammation measured using optical coherence tomography. (a): Vitreous/retinal pigmented epithelium relative signal intensity; (b): total area of opacities to show changes in total immune response; (c): mean number of opacities to quantify immune cells. N-L Ms cohort with non-loaded microspheres; MsDexa cohort with microspheres loaded with dexamethasone; MsDexaFibro cohort with microspheres loaded with dexamethasone and fibronectin; EPIm cohort with sclerosis of the episcleral veins. *: statistical significance (p < 0.05) between glaucoma models and healthy controls (ANOVA); #: statistical significance between the episcleral vein sclerosis model and each microsphere model by Scheffé test. Note that at later times, differences were found between EPIm and some of the microsphere models, (data not shown). Differences were only included when found between the EPIm model and each of the microsphere models. As can be seen, this occurred only at earlier times.