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. 2022 Nov 30;12:20622. doi: 10.1038/s41598-022-24954-4

Table 1.

Physical and chemical characterization of the microsphere formulations used to create the different ocular hypertension animal models. Production yield (%); Mean particle size and particle size distribution, external morphology (SEM: scanning electron microscopy; Jeol, JSM-6335F, Tokyo, Japan), dexamethasone loading (µg DX/mg Ms) according to direct quantification after extraction from the microspheres (Ms), and fibronectin loading (ng FN/mg Ms) indirectly obtained as the final point of cumulative release in the in vitro release assay.

N-L Ms MsDexa MsDexaFibro
Production yield (%) 39.37 77.34 55.14
Mean particle size (μm) 14.07 ± 1.07 13.13 ± 0.60 14.81 ± 0.30
Particle size distribution monodisperse monodisperse monodisperse
External morphology (SEM)

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Non-porous &

smooth surface

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Non-porous &

smooth surface

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Slightly porous & smooth surface
Dx loading (µg DX/mg Ms) – 60.70 ± 1.03 71.94 ± 2.40

FN loading

(ng DX/mg Ms)

 – – 74.47 ± 0.06