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Setting UMI depth quality-control thresholds using multimodal assays. (A) Mean gene activity (snATAC-seq) of LOY and non-LOY/normal nuclei (classified using snRNA-seq) as the minimum UMI count threshold is increased (snRNA-seq). Black line indicates the UMI depth threshold used in subsequent LOY analyses (more than 3000 UMI). (B) Mean gene activity of each detected MSY gene for LOY (red) and non-LOY/normal nuclei (gray).
