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. 2022 Oct;32(10):1941–1951. doi: 10.1101/gr.276960.122

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© 2022 Mercuri et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — FISH validation of a 17-Mbp inversion. NSI Strand-seq view of NLE Chromosome 22a and HSA Chromosome 2 shows the incomplete switch in the orientation of 17 Mbp against both reference genomes, suggesting the presence of a heterozygous inversion (Chr2_inv16). Metaphase FISH experiments in human, NSI, and NLE show that the region is inverted in heterozygous state only in NSI and is in direct orientation in both human and NLE. (HSA) Homo sapiens; (NSI) Nomascus siki; (NLE) Nomascus leucogenys.