Table 3.
Reported side effects associated with a) medication given in the session, and b) tDCS during stimulation in each session.
| a) | ||||
|---|---|---|---|---|
| Subject | Medication given in the respective session (symptoms) | |||
| A | BROMO + CYC50 (nausea) | |||
| B | BROMO + CYC100(nausea) | BROMO + CYC200 (nausea) | ||
| C | BROMO + CYC50 (nausea) | BROMO + PLC (nausea, vomiting) | L-Dopa + CYC100 (nausea) | |
| D | BROMO + CYC100 (nausea) | |||
| E | BROMO + CYC200 (nausea, vomiting) | |||
| F | L-Dopa + CYC200 (nausea) | |||
| b) | ||||
| Side effect | Placebo | |||
| PLC + PLC | PLC + CYC200 | PLC + CYC100 | PLC + CYC50 | |
| Visual | 0.00 | 0.090 ± 0.301 | 0.00 | 0.00 |
| Itching | 1.727 ± 1.103 | 1.363 ± 1.120 | 1.545 ± 1.128 | 1.272 ± 1.103 |
| Tingling | 1.454 ± 0.687 | 1.000 ± 0.447 | 1.272 ± 0.904 | 1.545 ± 1.128 |
| Burning | 0.636 ± 0.674 | 0.909 ± 1.044 | 1.000 ± 1.000 | 1.181 ± 1.328 |
| Pain | 0.272 ± 0.904 | 0.00 | 0.454 ± 0.820 | 0.272 ± 0.467 |
| BROMO | ||||
| PLC + BROMO | BROMO + CYC200 | BROMO + CYC100 | BROMO + CYC50 | |
| Visual | 0.00 | 0.00 | 0.00 | 0.00 |
| Itching | 1.000 ± 0.894 | 1.636 ± 1.026 | 1.181 ± 1.167 | 1.363 ± 0.924 |
| Tingling | 1.000 ± 0.632 | 1.363 ± 0.924 | 1.000 ± 1.264 | 1.363 ± 0.504 |
| Burning | 0.909 ± 1.044 | 1.454 ± 1.035 | 1.000 ± 1.000 | 1.363 ± 0.809 |
| Pain | 0.181 ± 0.603 | 0.181 ± 0.404 | 0.363 ± 0.504 | 0.454 ± 0.687 |
| L-Dopa | ||||
| PLC + L-Dopa | L-Dopa + CYC200 | L-Dopa + CYC100 | L-Dopa + CYC50 | |
| Visual | 0.00 | 0.00 | 0.00 | 0.00 |
| Itching | 1.090 ± 0.700 | 1.818 ± 1.328 | 1.727 ± 1.4206 | 1.545 ± 0.934 |
| Tingling | 1.454 ± 0.820 | 1.000 ± 1.095 | 1.181 ± 0.750 | 1.454 ± 0.820 |
| Burning | 0.909 ± 0.700 | 1.181 ± 0.981 | 1.181 ± 0.750 | 1.090 ± 0.943 |
| Pain | 0.454 ± 0.522 | 0.272 ± 0.646 | 0.363 ± 0.504 | 0.272 ± 0.467 |
Note: a) Occurrence and quality of side effects in single subjects under different medication conditions. b) The presence and intensity of tDCS-related side effects were rated on a numerical scale ranging from 0 to 5, 0 representing no and 5 extremely strong sensations. Data are presented as mean ± SD. tDCS = transcranial direct current stimulation, PLC = Placebo; CYC = D-cycloserine; BROMO = Bromocriptine.