Table 3.
Significant correlations between component scores and insula-to-whole-brain FC in OCD.
| Peak coordinates | Other regions included within cluster (>30 voxels) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BA | k | x | y | z | T | BA | Regions [aal labels/TD labels] | |||
| Higher Component 1 scores were associated with greater FC in: | ||||||||||
| Seed: Left dorsal anterior insula (−38 6 2) | ||||||||||
| L Precuneus | - | 799 | −18 | −46 | 2 | 5.76 | 19 | Posterior cingulate, R Lingual gyrus, R Fusiform gyrus, R Parahippocampal gyrus, R Calcarine, Cerebellar vermis IV–V | ||
| L Lingual gyrus | 30 | −12 | −40 | −4 | 5.36 | |||||
| L Calcarine | 30 | −16 | −54 | 4 | 5.31 | |||||
| L Cerebellum Crus I | - | 183 | −16 | −84 | −24 | 4.60 | 18 | Lingual gyrus | ||
| L Cerebellum Crus I | - | −6 | −82 | −18 | 4.16 | |||||
| L Cerebellum Crus I | - | −26 | −84 | −26 | 3.96 | |||||
| L Precuneus | - | 243 | −10 | −58 | 72 | 4.43 | 7 | Postcentral gyrus, superior parietal gyrus | ||
| L Precuneus | - | −6 | −48 | 74 | 4.13 | |||||
| L Precuneus | - | −6 | −66 | 66 | 4.08 | |||||
| R Precuneus | 7 | 340 | 12 | −70 | 58 | 4.13 | - | L Superior parietal gyrus | ||
| R Precuneus | - | 4 | −56 | 70 | 4.03 | |||||
| R Precuneus | - | 12 | −64 | 64 | 3.81 | |||||
| R Interior parietal gyrus | - | 165 | 34 | −50 | 40 | 3.97 | 40 | - | ||
| R Superior parietal gyrus | - | 40 | −50 | 56 | 3.96 | |||||
| R Postcentral gyrus | 2 | 38 | −42 | 64 | 3.56 | |||||
| Seed: Left posterior insula (−38 –6 5) | ||||||||||
| L Parahippocampal gyrus | - | 144 | −18 | −14 | −28 | 4.62 | - | - | ||
| Pons | - | −8 | −18 | −30 | 4.56 | |||||
| Higher Component 1 scores were associated with less FC in: | ||||||||||
| Seed: Right posterior insula (35 –11 6) | ||||||||||
| R Olfactory | 25 | 132 | 4 | 20 | −4 | 4.71 | - | - | ||
| R Subgenual anterior cingulate | - | 12 | 36 | 0 | 4.69 | |||||
| Lower Component 2 scores were associated with less FC in: | ||||||||||
| Seed: Right ventral anterior insula (32 10 –6) | ||||||||||
| R Anterior cingulate | - | 353 | 14 | 32 | 28 | 5.48 | - | Middle frontal gyrus, R Middle cingulate | ||
| L Anterior cingulate | 32 | −12 | 28 | 30 | 4.86 | |||||
| L Middle cingulate | - | 0 | 26 | 32 | 4.77 | |||||
| Lower Component 3 scores were associated with greater FC in: | ||||||||||
| Seed: Left dorsal anterior insula (−38 6 2) | ||||||||||
| L Interior frontal gyrus, triangularis | 46 | 779 | −50 | 30 | 18 | 5.79 | 45 | L Inferior frontal gyrus (opercularis), L Middle frontal gyrus | ||
| L Interior frontal gyrus, triangularis | - | −48 | 36 | 8 | 5.69 | |||||
| L Interior frontal gyrus, triangularis | 46 | −54 | 22 | 26 | 5.06 | |||||
| Seed: Right dorsal anterior insula (35 7 3) | ||||||||||
| L Interior frontal gyrus, triangularis | - | 370 | −48 | 34 | 8 | 5.18 | 46 | Middle frontal gyrus | ||
| L Interior frontal gyrus, triangularis | - | −52 | 34 | 20 | 4.47 | |||||
| L Interior frontal gyrus, triangularis | - | −48 | 24 | 20 | 4.32 | |||||
Note: Clusters significant at P < 0.001 voxelwise (uncorrected) with FWE < 0.05 clusterwise correction. Sex and scan site were included as covariates-of-no-interest. Coordinates are in MNI space.