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. 2022 Nov 17;13:1026660. doi: 10.3389/fphar.2022.1026660

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Copyright © 2022 Xiao, Xu, Tan, Zhang, Wang, Wang, Yang, Bai, Song, Shi, Lyu, Zhang and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ZZKZ regulated the levels of serum 5-HT and its receptors in the gut of FD rats. (A) Concentration of 5-HT in serum. (B,C) The mRNA expression of tryptophan hydroxylase 1 (TPH1) and serotonin transporter (SERT) in gastric tissues. (D) The gene expression of gastric 5-HT receptors, including 5-HT_1A, 5-HT_2A, 5-HT₃, 5-HT₄, 5-HT₇ receptors. N = 6–8; *p < 0.05 vs. HC; ^# p < 0.05 vs. FD.