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. 2022 Nov 17;15:806798. doi: 10.3389/fnmol.2022.806798

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Copyright © 2022 Hosoi, Akita, Watanabe, Ito, Miyajima and Fukuda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Passive membrane properties of somatosensory layer II/III pyramidal neurons in heterozygous (HT) and homozygous (Homo) TauT KO mice and wildtype (WT) littermates. (A) Comparison of cellular membrane capacitance around the soma. The numbers in brackets indicate the numbers of neurons analyzed. These are the same in all the figures except Figure 6 in this study. WT: 109.4 ± 6.1 pF, HT: 119.8 ± 7.6 pF, Homo: 113.9 ± 5.6 pF, p = 0.535 by ANOVA. (B) RMP. WT: −81.1 ± 1.6 mV, HT: −82.1 ± 1.8 mV, Homo: −86.3 ± 1.7 mV, p = 0.067 by ANOVA. (C) Input resistance. WT: 329.3 ± 21.2 MΩ, HT: 311.2 ± 25.1 MΩ, Homo: 284.8 ± 22.1 MΩ, p = 0.379 by ANOVA. NS, not significant. (A–C) Symbols indicate the values in individual neurons, and thick horizontal bars with error bars indicate means ± SEMs.