Table 1.

Tools granted with the gold or silver standard of reproducibility classification as adapted from Heil et al. [35]. Most of them are designed to predict anticancer or antimicrobial activities, which account for the majority of peptide tools as observed in Fig. 1.

Tool name	Activity prediction	Reference
ACP-MHCNN	Anticancer	[20]
CancerGram	Anticancer	[18]
DeepACP	Anticancer	[19]
iACP-FSCM	Anticancer	[21]
amPEPpy 1.0	Antimicrobial	[16]
AmpGram	Antimicrobial	[14]
AMPlify	Antimicrobial	[17]
PredAPP	Antiparasitic	[22]
PPTPP	Antiangiogenic; Antibacterial; Anticancer; Antiinflamatory; Antiviral; Cell-penetrating; Quorum sensing; Surface-binding	[24]
Ampir	Antimicrobial	[15]
Macrel	Antimicrobial	[13]
MLBP	Anticancer; Antihypertensive; Antiinflamatory; Antimicrobial	[25]
PreAntiCoV	Antiviral	[23]