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Summary of the mechanism of inspiratory hyperoxia supresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway. Hyperoxia treatment (60% oxygen (O2)) reduces the expression level of MYC, resulting in downregulation of the MYC target gene SLC1A5 in NSCLC cells. Low levels of SLC1A5 lead to disturbance in glutamine uptake and catabolism, ultimately leading to a reduction in lung cancer cell invasiveness and inhibition of metastasis. PR: promoter region.
