Table 2.
Synthesis matrix of articles collected in a literature review that report the antibacterial potential of natural Chalcones against S. aureus
| Chalcone | Type | S. aureus strain(s) | MIC/Inhibition Zone | Activity | Quotes |
|---|---|---|---|---|---|
|
4′-Hydroxy-3–4-dimethoxy-chalcone (1); 3′-Hydroxy-3-acetate, 4-methoxy-chalcone (3); 3′,4′-dihydroxy, 3,4,4′-trimethoxy-chalcone (4); 3,4-dimethoxy-chalcone (5) |
Nature Isolated from Arrabidaea brachypoda |
ATCC 25,923; IS-58; RN-4220; SA1199-B; K2068; K4414; K4100 | 1024; ≥ 1024 μg/mL | Inactive for antibacterial activity | Rezende-JúNIOR et al. (2020) |
| 3′,4′-dihydroxy, 3,4,4′-trimethoxy-chalcone (4) |
Nature Isolated from Arrabidaea brachypoda |
SA1199-B |
16 µg / mL 4X |
NorA efflux pump inhibitor | Rezende-JúNIOR et al. (2020) |
| Lophirones B, C | Nature, isolated from Lophira alata | ATCC 29,213 | 150 – 200 µg/ml | Antibacterial | Ajiboye and Haliru (2016) |
| 4,4′,6′ trihydroxy 3 methoxy 3′ pentene chalcone | Nature, isolated from Elatostema parasiticum | ATCC 6538 | 7.8 μg/ml | Antibacterial | Mariani et al. (2016) |
| Grandiflorone | Nature, isolated from Leptospermum scoparium | - | 16–32 μg/ml | Antibacterial | Killeen et al. (2016) |
| 2ʹ,4ʹ-dihydroxychalcone e 2ʹ,4ʹ-dihydroxy-3ʹ-methoxychalcone |
Nature Isolated from Zuccagnia punctata Cav |
ATCC 29,213, MRSA, MRSCN | 250 µg/mL−1 | Antibacterial | Moreno et al. (2015) |
| Cinnamaldehydo and its Chalcones derivatives |
Nature Isolated from Cinnamomum verum |
MRSA | 3.21 ± 40.0 mm | Antibacterial | Khayyat and Saddiq (2015) |
|
2′,4′-dihydroxychalcone 7-hydroxyflavanone |
Nature Isolated from Flourensia oolepis |
ATCC 6538 |
31 μg/mL 62 μg/mL |
Antibacterial | Joray et al. (2015) |
| Xanthoangelol | Nature, isolated from Angelica keiskei | ATCC 25,923, ATCC 700,699 (MRSA) |
6,25 µM 3,12 µM |
Antibacterial | Meier et al. (2019) |
|
Isobavachalcone; corylifol B |
Nature, isolated from Psoralea corylifolia L | MRSA OM481 OM584 | 8—16 µg/mL | Antibacterial | Cui et al. (2015) |
| 20 -hydroxy-4,40,60 -trimethoxychalcone, 20 -hydroxy-4,40,60 -tetramethoxychalcone, and 3,20 -dihydroxy-4,40,60 -trimethoxychalcone | Nature, isolated from hispidum | ATCC 25,923 | 62,5 mg/mL—125 µg/ml | Antibacterial and anti-biofilm | Costa et al. (2013) |
| Prenylated Chalcones (xanthohumol and Desmethylxanthohumol) | Nature, isolated from Humulus lupulus L | 8146, 8147, CIP 224, T1.1, T25.10, T25.3, T25.9, T26A4, T28.1, T36B1, T47A12, T6.7 | 9,8 – 19,5 µg/ml | Antibacterial, synergism with gentamicin, amoxicillin and vancomycin and anti-biofilm | Bocquet et al. (2019) |
| Lophirones B, C | Nature, isolated from Bamburu village | ATCC 29,213 | Redução da MIC | Antibacterial | Ajiboye and Haliru (2016) |
| Calythropsin | Nature, isolated from Calicotome villosa | - |
18 ± 1.4 mm 6 ± 0.7 mm |
Antibacterial | Alhage et al. (2018) |
| Diuvaretin, Uvaretin and Iso-Uvaretin | Nature, isolated from Uvaria chamae | ATCC 25,923, | 0,0046 mg/mL | Antibacterial | Koudokpon et al. (2018) |
| Basalcone J |
Nature, isolated from Populus Balsamifera |
ATCC 25,923 |
0.61 μM 6 μM |
Antibacterial | Simard et al. (2015) |
| 20 -hydroxy-4,40 -dimethoxy-chalcone and isoliquiritigenin | Nature, isolated from Coreopsis tinctoria Nutt | - | Redução de MIC | Antibacterial | Begmatov et al. (2020) |
| 5′-O-Methyl-3-hydroxyflemingin A and 5′-O-Methylflemingin C | Nature, isolated from Desmodium congestum |
ATCC 43,300, NRSA-NRS 17, NRSA-NRS 1 |
32 μg/mL | Antibacterial | Rees et al. (2015) |
| Isosalipurposide | Nature, isolated from Corylopsis coreana |
693E, MRSA 693E |
1.23 ± 0.06 cm | Antibacterial | Seo et al. (2016) |
| Homoembelin | Nature | ATCC 1026, SA3, SA4, SA11, SA12, MRSA 3, MRSA 4, MRSA 6, MRSA 8 | ≥ 256 µg/mL | Inactive for antibacterial activity | Omosa et al. (2016) |
| Xanthoangelol |
Nature Derived from Amorpha fructicosa |
ATCC 700,699 (MRSA) |
3.125 µM 12,5 µM |
Antibacterial Bactericidal |
Meier et al. (2019) |
|
2', 4'-dihydroxychalcone (DHC) |
Nature Isolated from Zuccagnia punctata Cav |
(F2, F5, F7, F8, F22, F23) and F31 |
(25 µg/mL) *100 µg/mL |
Antibacterial | Nuño et al. (2018) |
|
2', 4'-dihydroxy-3'-methoxycalcone (DMHC) |
Nature Isolated from Zuccagnia punctata Cav |
(F2, F5, F7, F8, F22, F23) and F31 |
(25 µg/mL) *100 µg/mL |
Antibacterial | Nuño et al. (2018) |
|
2', 4'-dihydroxychalcone (DHC) |
Nature Isolated from Zuccagnia punctata Cav |
F7 ATCC 25,923 |
12,5 µg/mL | Anti-biofilm | Nuño et al. (2018)) |
| Isoliquiritigenin |
Nature Isolated from Platymiscium gracile Benth |
ATCC 29,223 | 62,5 µg/mL | Low antibacterial activity | Cuellar et al. (2020) |
a) The spaces filled with (-) mean that the information was absent from the article or was not clear