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. 2022 Nov 17;12:1039888. doi: 10.3389/fonc.2022.1039888

Table 2.

Univariate and multivariate Cox regression analysis for OS.

Univariate Cox model Multivariate Cox model
HR (95% CI) P HR (95% CI) P
Age 1.034 (1.024-1.045) < 0.001 1.024 (1.011 -1.037) 0.001
Female 0.988 (0.705-1.384) 0.944
III–IV stage 2.140 (1.429-3.204) < 0.001 1.899 (1.194 -3.02) 0.014
ASCT 0.505 (0.305-0.836) 0.008 0.478 (0.242 -0.945) 0.034
PR to the 1st treatment 2.824 (2.060-3.873) < 0.001 2.687 (1.859 -3.884) < 0.001
ALK+ALCL 0.101 (0.041-0.245) < 0.001 0.478 (0.242 -0.945) 0.003
ECOG ≥2 (%) 1.507 (0.851-2.668) 0.159
LDH ≥ULN (%) 1.531 (1.070-2.191) 0.020 1.138 (0.774 -1.673) 0.584
B symptoms (%) 1.112 (0.299-4.128) 0.875

ALK+ALCL, anaplastic large-cell lymphoma; anaplastic lymphoma kinase positive; ECOG, Eastern Cooperative Oncology Group performance status; LDH, lactate dehydrogenase; ULN, upper limit of normal; HR, hazard ratio; ASCT, autologous stem cell transplantation; PR, partial response.