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Model of FMRP-mediated translational repression via a ncRBD. FMRP can bind mRNA through canonical and noncanonical RBDs. When bound to mRNA through its canonical KH domain(s), FMRP does not robustly inhibit translation. The RGG box motif and CTD of FMRP together form a ncRBD that allows FMRP to bind multiple mRNAs and subsequently inhibit translation to cause accumulation of slowed/stalled ribosomes. CTD, C-terminal domain; KH, K homology; ncRBD, noncanonical RNA-binding domain.
