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. 2022 Nov 30;612(7939):301–309. doi: 10.1038/s41586-022-05448-9

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© The Author(s), under exclusive licence to Springer Nature Limited 2022, corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Extended Data Fig. 8 — A-C. Forest plots and tables featuring hazard ratio (HR) estimates from cox-proportional hazard models are shown, with error bars that represent a 95% confidence interval. CHIP and its most common subtypes are significantly associated with acute myeloid leukemia (AML) (A), Myelodysplastic Syndromes (MDS) (B), and myeloproliferative neoplasm (MPN) (C). Here, results are depicted from analyses in which we removed samples that had a diagnosis of malignant cancer prior to sequencing collection. Models are adjusted for sex, LDL, HDL, pack years, smoking status, BMI, essential primary hypertension, type 2 diabetes mellitus, and 10 European specific genetic PCs. Hazard ratios (HR) were estimated using cox-proportional hazard modeling, with p-values uncorrected and derived from two-sided Wald tests.