Extended Data Fig. 2. Count Distribution and Pairwise Enrichments of Clonal Hematopoiesis of Indeterminate Potential (CHIP) Gene Mutations.

A. Total number of individuals with mutations (y axis, log₁₀ scale) in each of the 23 genes that were used to determine CHIP status across the UKB (blue) and GHS (red) CHIP callsets. B-C. Pairwise mutation counts across the UKB (B) and DiscoverEHR (C) callsets across individuals with at least two identified CHIP mutations. The color scale reflects the significance of the p-value for association between mutated CHIP gene pairs as determined by logistic regression. Per CHIP gene pair, these models included CHIP gene 1 mutation carrier status as the outcome, CHIP gene 2 mutation carrier status as the predictor, and age, sex, and smoking status (ever vs never) as covariates. P values are log₁₀ transformed (see Table S1 for complete enrichment results).