TABLE 3.
Relapse prediction model based on maximum recipient chimerism (%max) in samples taken >30 days before relapse
| Blood | All | Pediatric | Adult | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable | p‐Value | OR | CI 95% | P‐Value | OR | CI 95% | P‐Value | OR | CI 95% |
| CD19 | 0.23 | 1.20 | 1.02–1.75 | 0.6 | 1.07 | 0.99–1.99 | 0.30 | 1.28 | 1.00–2.13 |
| CD3 | 0.04 | 1.22 | 1.05–1.54 | 0.10 | 1.51 | 1.10–3.21 | 0.27 | 1.11 | 0.99–1.46 |
| CD33 | 0.05 | 1.70 | 1.12–3.09 | 0.18 | 1.39 | 1.04–2.95 | 0.03 | 3.53 | 1.34–13.2 |
| Multivariable | |||||||||
| CD3 | 0.03 | 1.25 | 1.06–1.60 | 0.07 | 1.63 | 1.12–3.81 | ‐ | ‐ | ‐ |
| CD33 | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | 0.02 | 4.03 | 1.49–15.5 |
| Patient age | 0.16 | 0.97 | 0.93–1.03 | 0.75 | 1.04 | 0.81–1.37 | 0.05 | 0.94 | 0.87–1.00 |
| MAC versus RIC | 0.64 | 0.69 | 0.16–3.40 | 1.00 | ‐ | ‐ | 0.35 | 0.43 | 0.07–2.57 |
| BM versus PB | 0.05 | 4.7 | 1.13–27.1 | 0.09 | 4.84 | 0.81–41.6 | 0.93 | 1.14 | 0.03–40.0 |
| ATG | 0.54 | 0.68 | 0.19–2.36 | 0.37 | 3.67 | 0.28–173 | 0.54 | 0.60 | 0.12–3.32 |
| Bone Marrow | |||||||||
| Univariable | |||||||||
| CD19 | 0.01 | 1.15 | 1.04–1.29 | 0.03 | 1.33 | 1.07–1.84 | 0.09 | 1.10 | 0.99‐1‐25 |
| CD3 | 0.003 | 1.25 | 1.10–1.47 | 0.08 | 1.26 | 1.06–1.76 | 0.02 | 1.24 | 1.06–1.52 |
| CD33 | 0.008 | 1.21 | 1.07–1.42 | 0.1 | 1.34 | 1.02–2.16 | 0.04 | 1.18 | 1.03–1.42 |
| CD34 | 0.03 | 1.07 | 1.01–1.14 | 0.05 | 1.12 | 1.01–1.27 | 0.20 | 1.05 | 0.97–1.13 |
| Multivariable | |||||||||
| CD3 | 0.004 | 1.24 | 1.09–1.46 | 0.05 | 1.27 | 1.07–1.75 | 0.02 | 1.26 | 1.05–1.57 |
| Patient age | 0.26 | 0.98 | 0.93‐1‐01 | 0.96 | 0.99 | 0.81‐1‐30 | 0.18 | 0.96 | 0.90–1.02 |
| MAC versus RIC | 0.99 | 1.01 | 0.24–4.84 | 1.00 | ‐ | ‐ | 0.87 | 0.88 | 0.18–4.56 |
| BM versus PB | 0.10 | 3.5 | 0.86–18.5 | 0.11 | 4.36 | 0.74–34.7 | 0.41 | 0.27 | 0.01–8.73 |
| ATG | 0.26 | 0.92 | 0.29–3.09 | 0.96 | 3.05 | 0.26–90.9 | 0.71 | 0.76 | 0.18–3.46 |
Note: Logistic regression analysis results are presented. Certain covariates in the pediatric subsets have been excluded due to few occurrences in the data set.
Abbreviations: ATG, antithymocyte globulin pretreatment; BM, bone marrow stem cell source; CI, confidence interval; MAC, myeloablative conditioning; n, number of patients; OR, odds ratio; PB, peripheral blood stem cell source; RIC, reduced intensity conditioning.