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. 2022 Nov 17;12:1004324. doi: 10.3389/fonc.2022.1004324

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Copyright © 2022 Yang, Yuan, Ren, Wang, Zhao, Zhao, Zhao, Chen, Jiang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of MCM4 inhibits glioma cell proliferation. (A, B) The knock-down efficiency of MCM4 in glioma cell lines was examined by qRT-PCR assay. (C, D) Depletion of MCM4 inhibits glioma cell proliferation examined by CCK-8 assay. (E, F) Depletion of MCM4 increased G0/G1 phase arrested cells. (G, H) The expression of EXTL3-AS1 and miRNA-24-3p in glioma cell lines was examined by qRT-PCR assay. shRNA#1=MCM4 shRNA#1, ShRNA#2=MCM4 shRNA#2. **p < 0.01, ***p < 0.001.