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. 2022 Nov 2;25(12):105471. doi: 10.1016/j.isci.2022.105471

Figure 2.

Figure 2

The decoding process of GwAAP

(A) MS and MS/MS spectra of the code peptide YPYDVPDYAGGVYR (Hkx1p, m/z 817.9779, 2+) in the DDA mode.

(B) A heatmap of 40 peptides containing their precursor and corresponding fragment ions.

(C) YPYDVPDYAGGVYR was targeted in PRM analyses, showing the dominant y9 fragment ion by cleavage at the N-terminal bond of the proline residue.

(D) Peak area contributions of the individual fragment ions of the peptide. The relative contribution of each fragment ion to each peptide peak is displayed as different colors.