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. 2022 Nov 17;25(12):105622. doi: 10.1016/j.isci.2022.105622

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Differential editing in AML

(A) Boxplots of Alu editing index (AEI) between AML patient samples (red) and healthy controls (blue) from BeatAML cohort.

(B) Boxplots of ADAR1 gene expression (CPM) between AML patient samples (red) healthy controls (blue) from BeatAML cohort.

(C) Boxplots of ADAR2 gene expression (CPM) between AML patient samples (red) healthy controls (blue) from BeatAML cohort.

(D) Boxplot of Alu editing index (AEI) plotted against the samples categorized based on their mutation status from TCGA AML dataset. Number of patient samples in each group is shown in parenthesis (GT2 genomic subgroups - greater than two genomic subgroups).

(E) Boxplot showing the differences in the ADAR1 expression levels (CPM) across TCGA AML genotypes. Number of patients in each group is shown in the parenthesis. Plotted are data points for each patient group, alongside the median, first and third quartile, and 95% confidence interval of median.