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. 2022 Nov 19;25(12):105642. doi: 10.1016/j.isci.2022.105642

Figure 7.

Figure 7

Human CCM lesions had abundant fibronectin, and KLF4- and pSMAD3-positive pericytes

(A) Representative T1-weighted (left panel) and T2-weighted (right panel) magnetic resonance images of human CCM lesions (n = 2).

(B) Representative IF images of CD31 and PDGFRβ in control subjects and human CCMs.

(C) Representative IF images of fibronectin and PDGFRβ. Abundant fibronectin accumulated in human CCMs.

(D and E) Representative IF images of PDGFRβ and pSMAD3. Human CCM lesions had predominant pSMAD3-positive pericytes (n = 2). White box regions in the left panels represent the typical regions at high magnifications on the right.

(F and G) Representative IF images show KLF4-positive pericytes in human CCM lesions (n = 2). White box regions in the left panels represent the typical regions at high magnifications on the right. Data are presented as mean ± SD. Scale bar: 10 μm in B-D, and F.