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. 2022 Nov 17;12:996489. doi: 10.3389/fonc.2022.996489

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Copyright © 2022 Lazow, Fuller, Trout, Stanek, Reuss, Turpin, Szabo and Salloum

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Membranous SST2A expression by histopathology. (A) Boxplot of total SST2A IHC score (y-axis) for pediatric CNS tumors of different histopathologic diagnoses (x-axis). The dashed gray line (corresponding to a total SST2A IHC score of 1) distinguishes between negative (0-1) and positive (≥2) SST2A IHC scores. (B) Bubble plot of mean SST2A IHC subscores (staining intensity score on y-axis, immunoreactivity score on x-axis) for different histopathologic diagnoses (indicated in black boxes), with circle size proportional to the number of patients analyzed within each respective histopathology group. The dashed horizontal and vertical gray lines (corresponding to staining intensity and immunoreactivity scores of 1, respectively) illustrate the subscore thresholds below which total SST2A IHC scores would be considered negative (0-1).