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. 2022 Nov 23;2022:9197940. doi: 10.1155/2022/9197940

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Copyright © 2022 Chengyi Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interactions between macrophage infiltrated in the injured area and macrophage/microglia. 7 days after SCI, most of the locally infiltrated macrophages/microglia express the M1 phenotype and secrete a large number of proinflammatory factors such as IL-1β, which aggravate the local inflammation of the injury. In recent works, we found that macrophages infiltrated in the spinal cord injured area can release Met. It may be a key factor in the M1 polarization of macrophage/microglia. This happens through LL37 triggering downstream NF-κB proinflammatory pathway via the activation of the P2X7R. However, limiting the number of Mets by using DNase I can promote the M2 polarization of macrophage/microglia and the release of anti-inflammatory factors such as IL-10. Therefore, Mets can be a new target for the treatment of SCI. SCI: spinal cord injury; IL: interleukin. Met: macrophage extracellular trap. P2X7R: P2X purinoreceptor 7.