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Flowchart for the efficient use of ATRX and HIP1R/VIM for the classification of IDH-mutant gliomas. Tumors with nuclear loss of ATRX can be classified as astrocytoma. Tumors with retained or nondeterminable ATRX status are evaluated with HIP1R/VIM immunohistochemistry. VIM > HIP1R tumors are classified as astrocytomas, VIM < HIP1R are classified as oligodendrogliomas. VIM = HIP1R tumors need molecular 1p/19q testing for classification.
