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. 2022 Nov 29:02601060221139628. doi: 10.1177/02601060221139628

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Figure 3. — (a) Humans cannot synthesise vitamin C due to lack of L-gluconolactone oxidase enzyme. Plants can synthesise ascorbate due to presence of L-gluconolactone oxidase enzyme. (b) Mechanism of action of vitamin C and (c) ascorbate molecule is impermeable to blood–brain barrier and lacks SVCT2 expression. ASC: ascorbate; DHA: dehydroascorbate; GLUT: glucose transporter; SVCT: sodium ascorbate co-transporter.