Table 2.

List of clinical trials for intervention of vitamin C in COVID-19 infections.

Serial number	Title	Country	Participants	Interventions	NCT number	Status
1	Coronavirus 2019 (COVID-19) – using ascorbic acid and zinc supplementation (COVID A to Z)	The United States	214	Ascorbic acid and zinc gluconate	NCT04342728	Completed
2	Administration of intravenous vitamin C in novel coronavirus infection (COVID-19) and decreased oxygenation (AVoCaDO)	The United States	20	50 mg/kg L-ascorbic acid of infusion given every 6 h for 4 days (16 total doses)	NCT04357782	Completed
3	High-dose vitamin C treatment in critically ill patients with COVID-19	Turkey	78	The daily administration of 6 g of vitamin C intravenously in 4 equal doses every 6 h	NCT04710329	Completed
4	Lessening organ dysfunction with vitamin – COVID-19 (lovit-covid)	Canada	800	Vitamin C Control: saline or 5% dextrose solution	NCT04401150	Recruiting
5	The effect of melatonin and vitamin C on COVID-19	The United States	150	(1) 10 mg melatonin, at bedtime (2) 1000 mg vitamin C, at bedtime Placebo at bedtime	NCT04530539	Recruiting
6	The study of quadruple therapy zinc, quercetin, bromelain and vitamin C on the clinical outcomes of patients infected with COVID-19	Saudi Arabia	60	1) Zinc:50 mg 2) Quercetin:500 mg 3) Bromelin:500 mg Vitamin C:1000 mg	NCT04468139	Recruiting
7	Use of ascorbic acid in patients with COVID-19	Italy	500	10 g* of vitamin C intravenously in addition to conventional therapy	NCT04323514	Recruiting
8	Safety study of early infusion of vitamin C for the treatment of novel coronavirus acute lung injury (SAVE EVICT CORONA-ALI)	The United States	60	50 mg/kg intravenous vitamin C infusion every 6 h for up to 96 h	NCT04344184	Recruiting
9	A study of hydroxychloroquine, vitamin C, vitamin D and zinc for the prevention of COVID-19 (HELPCOVID19)	The United States	600	Experimental: hydroxychloroquine, vitamin C, vitamin D, zinc Placebo: vitamin C, vitamin D, zinc	NCT04335084	Recruiting
10	Role of mega dose of vitamin C in critical patients with COVID-19 infection	Pakistan	15	Experimental: the dose was 30 g a day (10 g TDS) for 2 days with standard treatment Placebo: distilled water in the same dose with same standard treatment	NCT04682574	Recruiting
11	International alliance study of therapies to prevent progression of COVID-19	Australia	200	Vitamin C, Hydroxychloroquine Azithromycin Zinc citrate Vitamin D3, vitamin B12	NCT04395768	Recruiting
12	Vitamin C infusion for the treatment of severe 2019-ncov-infected pneumonia	China	56	Experimental: 12g vitamin C was infused in the experimental group twice a day for 7 days Placebo: 50 ml sterile water for injection will be infused in the placebo comparator group twice a day for 7 days	NCT04264533	Terminated

NCT: National Clinical Trial number.