Table 3.

List of clinical trials for interventions of vitamin C (ascorbic acid) in other health conditions.

Serial number	Title	Study type	Population	Interventions	NCT number	Status	Key findings
1	Micronutrient to prevent noise-induced hearing loss	Interventional study	70 participants	Beta-carotene, vitamins C and E, magnesium	NCT00808470	Completed	Supplement had no effect on noise-induced changes in hearing
2	Quantitative in vivo biomarkers of oxidative stress in diabetes	Interventional study	42 participants	Vitamin C	NCT00845130	Completed
3	Prophylaxis to reduce post-operative atrial fibrillation in cardiac surgery	Interventional study	304 participants	Beta blockers, amiodarone, ascorbic acid	NCT00953212	Completed
4	ACTS trial	Interventional study	205 participants	Vitamin C, vitamin B1, hydrocortisone	NCT03389555	Completed	The combination did not show significant reduction in the SOFA score
5	Intravenous vitamin C in the treatment of viral infection especially in the treatment of shingles	Interventional study	68 participants	IV vitamin C	NCT00921934	Completed	The results showed that there was decline in the pain score which provide evidence that IV vitamin C is beneficial in treatment of viral infection
6	A study of vitamin C in the treatment of liver cancer to determine if it is safe and effective	Interventional study	5 participants	Ascorbic acid & sorafenib	NCT01754987	Completed	The safety data indicates no toxicity
7	A phase 2 pharmacokinetic study of 6r-bh4 alone or 6r-bh4 with vitamin C in subjects with endothelial dysfunction	Interventional study	52 participants	Sapropterin dihydrochloride and vitamin C	NCT00532844	Completed
8	The effect of high-dose vitamin C on the liver function in chronic hepatitis patients	Interventional study	10 participants	High-dose vitamin C	NCT01413360	Completed
9	Liposomal encapsulated vitamin C in complex regional pain syndrome	Interventional study	66 participants	Liposomal vitamin C versus vitamin C versus placebo	NCT04204200	Completed	There was no benefit to patients and no significant difference in time to heal the fracture
10	Ascorbic acid (vitamin C) infusion in human sepsis	Interventional study	24 participants	Ascorbic acid	NCT01434121	Completed	Ascorbic acid significantly reduced the proinflammatory biomarkers C-reactive protein and procalcitonin
11	Vit C-AF	Interventional study	20 participants	Vitamin C	NCT03148236	Completed	High dose of vitamin C is safe and well tolerated at the time of AF ablation and is associated with a blunted rise in C-reactive protein
12	CITRIS-ALI	Interventional study	170 participants	Infusion: vitamin C	NCT02106975	Completed	The infusion of ascorbic acid did not significantly improve the organ dysfunction scores
13	Study of high-dose vitamin C on outcome in cardiac surgery patients	Interventional study	57 participants	Drug: ascorbic acid Placebo: 5% Dextrose water or normal saline	NCT01167569	Completed
14	VCSIP of infant lung infection	Interventional study	252 participants	Vitamin C	NCT01723696	Completed
15	Does vitamin C reduce finger stiffness after distal radius fractures?	Interventional study	126 participants	500 mg vitamin C, 1 pill per day for 6 weeks versus 1 placebo pill for 6 weeks	NCT02216812	Completed	There was no difference in the finger stiffness
16	VICTAS	Interventional study	501 participants	Vitamin C, thiamine hydrocortisone	NCT03509350	Completed
17	Vitamin C supplementation intervention	Interventional study	36 participants	Vitamin C 500 mg versus vitamin C 1000 mg versus placebo	NCT04036110	Completed	Patients with CHF acute intravenous administration of vitamin C enhances platelet responsiveness to the anti-aggregatory effects of NO donors and improves endothelial function

ACTS: Ascorbic acid, corticosteroids and thiamine in sepsis; AF: atrial fibrillation, CHF: congestive heart failure, CITRIS-ALI: vitamin C infusion for treatment is sepsis-induced acute lung injury; IV: intravenous; NCT: National Clinical Trial number; NO: nitric oxide; SOFA: Sequential Organ Failure Assessment; VCSIP: vitamin C to decrease effects of smoking in pregnancy; VICTAS: vitamin C, thiamine and steroids in sepsis; Vit C-AF: vitamin C in atrial fibrillation ablation.