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. 2021 Aug 5;107(12):2846–2858. doi: 10.3324/haematol.2021.278537

Figure 6.

Figure 6.

Thymosin |34 is required for thrombus formation and stability in vitro and in vivo. (A-C) Assessment of platelet adhesion (A, B) and aggregate formation (A, C) on Horm collagen (200 mg mL-1) under flow (150, 1,000 and 1,700 s-1) in heparinized whole blood or platelet-count adjusted blood of WT and Tmsb4x knockout (KO) mice. Values are mean ± standard deviation (SD) (n = 12). Scale bar, 50 mm. (D) Representative graph of blood flow of one WT and two Tmsb4x KO mice after mechanical injury of the abdominal aorta. (E) Occlusion times after mechanical injury of the abdominal aorta. Data are mean ± SD of at least 8 mice per group. Fisher’s exact test. **P<0.005. (F) Tail bleeding times in WT and Tmsb4x KO mice (filter paper method). Each symbol represents one individual. Unpaired, two-tailed Student’s t-test. **P<0.005. plt.: platelet.