Bioactivity of antivibrio compounds isolated from Actinobacteria.

No.	Compounds	Sources	Antivibrio activities	Mechanism of action	Ref.
1	Nanaomycin A (1)	Streptomyces rosa var. notoensis OS-3966	V. alginolyticus 138-2, MIC 6.3 μg mL−1, V. parahaemolyticus K-1, MIC 3.1 μg mL−1	Inhibition of inhibiting biosyntheses of protein, DNA, RNA, and cell-wall peptidoglycan	50
2	Nanaomycin D (2)	Streptomyces rosa var. notoensis OS-3966	V. alginolyticus 138-2, MIC < 0.05 μg mL−1, V. parahaemolyticus K-1, MIC < 0.05 μg mL−1	Affect respiratory chain-linked flavin dehydrogenases of a Vibrio alginolyticus	50
3	Munumbicin B (3)	Streptomyces NRRL 3052	V. harveyi PIC 345, dose 10 μg	Inhibition of the growth	51
4	Guadinomine B (4)	Streptomyces sp. K01-0509	Vibrio sp. IC50 14 nM	Inhibition of type III secretion system (TTSS) in Vibrio spp.	52
5	2-Hydroxy-5-(3-methylbut-2-enyl) benzaldehyde (5)	Streptomyces atrovirens PK288-21	V. anguillarum, MIC 65 μg mL−1, V. harveyi, MIC 20 μg mL−1	Inhibition of the growth	54
6	2-Hepta-1,5-dienyl-3,6-dihydroxy-5-(3-methylbut-2-enyl) benzaldehyde (6)	Streptomyces atrovirens PK288-21	V. anguillarum, MIC 65 μg mL−1, V. harveyi, MIC 32 μg mL−1	Inhibition of the growth	54
7	Actionin (7)	Streptomyces sp. NHF 165	V. anguillarum, IC50 2.85 μM	Inhibition of peptide deformylase (PDF) of V. anguillarum	55
8	Chaxalactin A (8)	S. leeuweenhoekii strain C38	V. parahaemolyticus, MIC 12.5 μg mL−1	Inhibition of the growth	56
9	Chaxalactin B (9)	S. leeuweenhoekii strain C38	V. parahaemolyticus, MIC 12.5 μg mL−1	Inhibition of the growth	56
10	Chaxalactin C (10)	S. leeuweenhoekii strain C38	V. parahaemolyticus, MIC 20 μg mL−1	Inhibition of the growth	56
11	Pyranosesquiterpene (11)	Streptomyces sp. SCSIO 01689	V. anguillarum, MIC > 100 μg mL−1	Inhibition of the growth	45
12	Cyclo(D)-Pro-(D)-Ile (12)	Streptomyces sp. SCSIO 01689	V. anguillarum, MIC 0.05 μg mL−1	Inhibition of the growth	45
13	Cyclo(D)-Pro-(D)-Leu (13)	Streptomyces sp. SCSIO 01689	V. anguillarum, MIC 0.04 μg mL−1	Inhibition of the growth	45
14	Cyclo(D)-trans-4-OH-Pro-(D)-Phe (14)	Streptomyces sp. SCSIO 01689	V. anguillarum, MIC 0.07 μg mL−1	Inhibition of the growth	45