Table 4.
The differential metabolites in fecal between LF and BC groups.
| Metabolites | rt | Mass | MeanLF | MeanBC | Trend | VIP | p-Value | FC |
|---|---|---|---|---|---|---|---|---|
| Amino acids and amino acid derivatives | ||||||||
| l-Serine | 389.699 | 106.050 | 1.437 | 3.838 | Up | 1.235 | 0.047 | 2.671 |
| l-Lysine | 532.865 | 147.112 | 3.324 | 19.025 | Up | 1.318 | 0.006 | 5.723 |
| beta-Alanine | 359.246 | 90.055 | 10.680 | 24.322 | Up | 1.243 | 0.024 | 2.277 |
| d-Ornithine | 547.123 | 133.097 | 0.386 | 1.065 | Up | 1.229 | 0.036 | 2.760 |
| d-Proline | 514.857 | 116.070 | 1.293 | 4.484 | Up | 1.316 | 0.010 | 3.467 |
| Tryptophan | 0.876 | 205.096 | 4.911 | 16.538 | Up | 1.242 | 0.018 | 1.717 |
| 5-Hydroxy-l-tryptophan | 297.080 | 221.091 | 0.051 | 0.190 | Up | 1.217 | 0.039 | 3.701 |
| l-Norleucine | 279.448 | 130.086 | 255.886 | 427.238 | Up | 1.283 | 0.045 | 1.670 |
| l-Valine | 313.992 | 118.086 | 24.588 | 58.664 | Up | 1.250 | 0.037 | 2.386 |
| l-Phenylalanine | 273.762 | 166.085 | 35.455 | 102.182 | Up | 1.275 | 0.029 | 2.882 |
| l-Tyrosine | 316.869 | 182.080 | 8.767 | 33.059 | Up | 1.225 | 0.027 | 3.771 |
| Prolylglycine | 311.634 | 173.091 | 0.045 | 0.160 | Up | 1.236 | 0.019 | 3.531 |
| l-Glutamic acid | 411.255 | 148.059 | 10.094 | 24.526 | Up | 1.204 | 0.035 | 2.430 |
| l-Asparagine | 389.770 | 133.060 | 3.387 | 9.566 | Up | 1.228 | 0.029 | 2.825 |
| Argininosuccinic acid | 484.113 | 291.127 | 0.052 | 0.179 | Up | 1.230 | 0.028 | 3.430 |
| Glutamyllysine | 506.193 | 276.153 | 0.014 | 0.089 | Up | 1.331 | 0.001 | 6.526 |
| Gamma-glutamyl ornithine | 465.060 | 262.138 | 0.116 | 0.419 | Up | 1.316 | 0.005 | 3.601 |
| Lysyl-Glycine | 470.018 | 204.133 | 0.543 | 1.578 | Up | 1.251 | 0.021 | 2.906 |
| Leucyl-Glycine | 120.022 | 189.122 | 1.042 | 2.057 | Up | 1.174 | 0.043 | 1.974 |
| Lysyl-Arginine | 572.540 | 303.211 | 0.080 | 0.462 | Up | 1.332 | 0.003 | 5.748 |
| Lysyl-Aspartate | 482.117 | 262.138 | 0.022 | 0.093 | Up | 1.276 | 0.028 | 4.164 |
| Aspartyl-Arginine | 456.445 | 290.143 | 0.254 | 0.816 | Up | 1.282 | 0.021 | 3.215 |
| Lysyl-Lysine | 574.436 | 275.206 | 0.043 | 0.237 | Up | 1.344 | 0.000 | 5.507 |
| Prolyl-Lysine | 485.670 | 244.164 | 0.412 | 1.618 | Up | 1.247 | 0.020 | 3.924 |
| Hydroxyprolyl-Arginine | 380.695 | 288.165 | 0.094 | 0.160 | Up | 1.171 | 0.048 | 1.706 |
| N 6-Acetyl-l-lysine | 403.155 | 189.122 | 0.108 | 0.230 | Up | 1.195 | 0.036 | 2.125 |
| Epsilon-(gamma-glutamyl)-lysine | 342.282 | 114.091 | 0.426 | 0.164 | down | 1.294 | 0.002 | 0.385 |
| Vinylacetylglycine | 445.764 | 144.065 | 0.948 | 1.564 | Up | 1.215 | 0.035 | 1.650 |
| N-Acetyldopamine | 389.971 | 196.096 | 0.052 | 0.139 | Up | 1.206 | 0.035 | 2.658 |
| 5-Aminopentanal | 268.421 | 102.091 | 0.855 | 1.795 | Up | 1.146 | 0.050 | 2.100 |
| 5-Aminopentanoic acid | 285.672 | 118.086 | 153.482 | 232.481 | Up | 1.193 | 0.037 | 1.515 |
| (3S,5S)-3,5-Diaminohexanoate | 358.914 | 147.112 | 0.082 | 0.127 | Up | 1.221 | 0.031 | 1.543 |
| Sphingolipids | ||||||||
| Sphinganine | 126.829 | 302.303 | 0.150 | 0.483 | Up | 1.245 | 0.030 | 3.213 |
| Dehydrophytosphingosine | 150.057 | 316.283 | 2.173 | 4.968 | Up | 1.266 | 0.018 | 2.286 |
| Phospholipids | ||||||||
| PC(15:0/15:0) | 165.938 | 706.534 | 0.876 | 2.051 | Up | 1.219 | 0.044 | 2.341 |
| PC(16:0/16:0) | 143.618 | 734.567 | 0.113 | 0.247 | Up | 1.166 | 0.049 | 2.182 |
| PC(16:1(9Z)/14:0) | 165.938 | 704.517 | 0.871 | 1.784 | Up | 1.224 | 0.027 | 2.048 |
| PC(16:1(9Z)/15:0) | 165.148 | 718.532 | 0.430 | 1.172 | Up | 1.282 | 0.006 | 2.726 |
| PC(18:1(11Z)/14:0) | 163.671 | 732.548 | 7.850 | 16.581 | Up | 1.262 | 0.017 | 2.112 |
| PC(16:1(9Z)/16:1(9Z)) | 164.080 | 730.535 | 2.463 | 5.134 | Up | 1.203 | 0.042 | 2.085 |
| PC(18:2(9Z,12Z)/18:0) | 158.697 | 786.596 | 11.337 | 23.771 | Up | 1.263 | 0.008 | 2.097 |
| PC(15:0/18:2(9Z,12Z)) | 163.281 | 744.549 | 0.774 | 1.979 | Up | 1.248 | 0.015 | 2.557 |
| PC(24:1(15Z)/14:1(9Z)) | 61.254 | 814.623 | 0.138 | 0.500 | Up | 1.257 | 0.012 | 3.630 |
| PC(20:2(11Z,14Z)/15:0) | 160.063 | 772.580 | 0.970 | 2.096 | Up | 1.263 | 0.013 | 2.162 |
| PC(16:1(9Z)/P-18:1(11Z)) | 157.795 | 742.570 | 0.117 | 0.261 | Up | 1.303 | 0.009 | 2.221 |
| PC(18:3(6Z,9Z,12Z)/15:0) | 163.278 | 742.532 | 0.383 | 0.964 | Up | 1.277 | 0.010 | 2.517 |
| PC(18:3(9Z,12Z,15Z)/14:0) | 164.912 | 728.519 | 0.237 | 0.600 | Up | 1.246 | 0.041 | 2.536 |
| PC(22:2(13Z,16Z)/16:1(9Z)) | 157.827 | 812.611 | 1.076 | 1.904 | Up | 1.194 | 0.042 | 1.769 |
| PC(18:3(6Z,9Z,12Z)/18:1(11Z)) | 59.786 | 782.561 | 4.189 | 14.056 | Up | 1.185 | 0.028 | 3.355 |
| PC(18:3(6Z,9Z,12Z)/P-18:1(11Z)) | 156.085 | 766.568 | 2.699 | 4.163 | Up | 1.169 | 0.046 | 1.542 |
| PC(18:4(6Z,9Z,12Z,15Z)/18:1(11Z)) | 60.817 | 780.549 | 5.307 | 23.397 | Up | 1.270 | 0.010 | 4.409 |
| PC(18:4(6Z,9Z,12Z,15Z)/P-18:1(11Z)) | 154.689 | 764.555 | 1.898 | 3.151 | Up | 1.242 | 0.013 | 1.661 |
| PC(20:2(11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) | 153.256 | 834.593 | 4.658 | 9.579 | Up | 1.230 | 0.044 | 2.056 |
| PC(22:5(7Z,10Z,13Z,16Z,19Z)/20:1(11Z)) | 150.997 | 862.623 | 0.162 | 0.494 | Up | 1.290 | 0.009 | 3.048 |
| PC(P-18:1(11Z)/22:5(4Z,7Z,10Z,13Z,16Z)) | 149.122 | 818.601 | 0.802 | 1.068 | Up | 1.237 | 0.042 | 1.332 |
| PE(P-16:0/20:5(5Z,8Z,11Z,14Z,17Z)) | 155.152 | 722.508 | 1.542 | 2.651 | Up | 1.181 | 0.048 | 1.719 |
| LysoPE(0:0/14:0) | 224.850 | 426.258 | 0.013 | 0.048 | Up | 1.235 | 0.022 | 3.755 |
| LysoPC(16:0) | 212.374 | 496.336 | 6.094 | 25.253 | Up | 1.253 | 0.021 | 4.144 |
| LysoPC(P-16:0) | 205.967 | 480.341 | 0.194 | 0.479 | Up | 1.250 | 0.020 | 2.470 |
| LysoPC(18:1(9Z)) | 209.520 | 522.353 | 14.907 | 66.989 | Up | 1.226 | 0.034 | 4.494 |
| SM(d18:1/16:0) | 200.851 | 703.569 | 0.195 | 0.937 | Up | 1.332 | 0.001 | 4.798 |
| SM(d18:1/20:0) | 197.867 | 759.630 | 0.029 | 0.118 | Up | 1.267 | 0.018 | 4.072 |
| SM(d18:0/18:1(9Z)) | 198.900 | 731.601 | 0.113 | 0.611 | Up | 1.319 | 0.002 | 5.425 |
| Other lipids | ||||||||
| (2E)-Decenoyl-ACP | 532.921 | 130.085 | 1.731 | 8.939 | Up | 1.317 | 0.007 | 5.164 |
| Phosphodimethylethanolamine | 460.647 | 170.057 | 0.123 | 0.561 | Up | 1.312 | 0.003 | 4.561 |
| 5α-Cholesta-8,24-dien-3-one | 31.273 | 383.328 | 0.201 | 0.341 | Up | 1.225 | 0.026 | 1.702 |
| Aromatic compounds | ||||||||
| Quinone | 223.123 | 109.028 | 0.106 | 0.386 | Up | 1.220 | 0.026 | 3.653 |
| Phenol | 316.869 | 95.049 | 0.194 | 0.763 | Up | 1.212 | 0.037 | 3.929 |
| Parabanic acid | 16.343 | 112.998 | 0.825 | 0.976 | Up | 1.495 | 0.012 | 1.183 |
| Benzaldehyde | 273.701 | 107.049 | 0.358 | 1.088 | Up | 1.291 | 0.022 | 3.037 |
| 4-Hydroxybenzaldehyde | 316.993 | 123.044 | 1.072 | 4.121 | Up | 1.221 | 0.031 | 3.844 |
| 2-Phenylacetamide | 184.356 | 128.143 | 11.688 | 20.587 | Up | 1.280 | 0.018 | 1.761 |
| 1H-Indole-3-carboxaldehyde | 276.993 | 146.059 | 0.518 | 1.876 | Up | 1.190 | 0.028 | 3.619 |
| 1H-Indole-2,3-dione | 47.215 | 148.038 | 0.163 | 0.464 | Up | 1.209 | 0.029 | 2.855 |
| Energy metabolism-related | ||||||||
| O-Phosphotyrosine | 492.769 | 262.049 | 0.271 | 1.058 | Up | 1.308 | 0.002 | 3.902 |
| Isocitral | 183.881 | 153.127 | 0.087 | 0.177 | Up | 1.147 | 0.041 | 2.034 |
| 3-Dehydroxycarnitine | 390.707 | 146.117 | 31.835 | 78.692 | Up | 1.260 | 0.018 | 2.472 |
| Secondary metabolites of plants | ||||||||
| 7-Hydroxy-2-phenyl-4H-chromen-4-one | 202.998 | 237.054 | 0.326 | 0.640 | Up | 1.569 | 0.011 | 1.961 |
| Glycitein | 145.862 | 307.060 | 0.154 | 0.317 | Up | 1.327 | 0.001 | 2.061 |
| Luteolin 4′-sulfate | 26.207 | 367.009 | 0.032 | 0.100 | Up | 1.318 | 0.001 | 3.154 |
| Momordicinin | 30.867 | 439.355 | 0.026 | 0.045 | Up | 1.311 | 0.002 | 1.708 |
| Isoquinoline | 137.025 | 130.064 | 0.099 | 0.269 | Up | 1.279 | 0.018 | 2.713 |
| 2-Propylpiperidine | 184.356 | 128.143 | 11.688 | 20.587 | Up | 1.280 | 0.018 | 1.761 |
| Pipericine | 1.954 | 336.324 | 0.007 | 0.016 | Up | 1.139 | 0.044 | 2.296 |
| Nucleotides and nucleotide derivatives | ||||||||
| 8-Hydroxyguanine | 309.359 | 168.051 | 0.253 | 0.403 | Up | 1.189 | 0.045 | 1.593 |
| Pyrimidine | 172.823 | 81.045 | 0.134 | 0.585 | Up | 1.259 | 0.043 | 4.361 |
| 3-Aminoisobutanoic acid | 350.392 | 102.055 | 0.655 | 1.177 | Up | 1.500 | 0.027 | 1.796 |
| Cyclic AMP | 281.191 | 328.044 | 0.319 | 1.564 | Up | 1.461 | 0.041 | 4.903 |
| 3′-AMP | 420.136 | 346.055 | 0.424 | 0.863 | Up | 1.330 | 0.041 | 0.662 |
| Vitamin D3 | 31.910 | 385.343 | 0.164 | 0.326 | Up | 1.204 | 0.039 | 1.988 |