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. 2022 Nov 17;13:1066988. doi: 10.3389/fphar.2022.1066988

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Copyright © 2022 Nazarova, Sokolov, Chubarev, Tarasov and Schiöth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Most common drug targets in ADHD trials. This figure shows targets with the highest number of unique agents drugging the corresponding target in ADHD clinical trials. If a drug had multiple targets, all of these targets were included in the analysis. Protein names have been used to distinguish targets. In total, 12 most common drug targets were included in the figure: sodium-dependent noradrenaline transporter (SLC6A2), sodium-dependent dopamine transporter (SLC6A2), D (2) dopamine receptor (DRD2), sodium-dependent serotonin transporter (SLC6A2), neuronal acetylcholine receptor subunit alpha-4 (CHRNB2), neuronal acetylcholine receptor subunit beta-2 (CHRNA4), 5-hydroxytryptamine receptor 2A (HTR2A), synaptic vesicular amine transporter (SLC18A2), histamine H3 receptor (HRH3), alpha-2A adrenergic receptor (ADRA2A), neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) and alpha-2C adrenergic receptor (ADRA2C). (B) Drug target types in ADHD studies. All data regarding drug target type was collected from go.drugbank.com, genome. jp, and uniprot.org. In order to construct this figure, all unique gene names used in the analysis (82 in total) were taken and then transformed into protein names. Then corresponding proteins have been classified according to four target types: receptor, enzyme, ion channel, transporter. For the gene names S100B (S100 Calcium Binding Protein (B), CARTPT (Cocaine- and amphetamine-regulated transcript protein), and M (Matrix protein 2) no information about the protein type was found, and thus they were placed in group “other”. The data is due 4 January 2021.