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. 2022 Nov 16;7(47):43321–43328. doi: 10.1021/acsomega.2c06814

Table 1. Stability of 67Ga-Labeled Model Chelatorsa.

  murine plasma
ApoTf (0.1 mM)
  3 h 24 h 3 h 24 h
[67Ga]Ga-p-NO2-Bn-DOTA (A) 97.6 ± 0.3cdef 95.9 ± 0.1cdef 95.1 ± 1.2def 90.3 ± 0.7cdef
[67Ga]Ga-p-NO2-Bn-DOTA (B) 96.2 ± 0.4b 85.9 ± 0.4bcde 89.5 ± 0.7bcde 56.0 ± 0.5bcde
[67Ga]Ga-DOTAGAMBu 96.1 ± 0.4b 82.2 ± 0.2bcd 80.0 ± 1.3bcd 27.5 ± 4.6bcd
[67Ga]Ga-DO3AMBu 96.1 ± 0.6b 83.9 ± 0.5bc 87.4 ± 0.5bc 43.1 ± 1.1bc
[67Ga]Ga-p-NO2-Bn-DO3A 96.7 ± 0.5 87.6 ± 0.3b 93.8 ± 0.6b 67.5 ± 0.6b
[67Ga]Ga-DOTA 97.5 ± 0.5 95.5 ± 0.4 96.4 ± 0.2 89.6 ± 0.5
a

Results are expressed as mean ± SD (n = 5).

b

Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with [67Ga]Ga-DOTA.

c

Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-p-NO2-Bn-DO3A.

d

Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-DO3AMBu.

e

Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-DOTAGAMBu.

f

Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-p-NO2-Bn-DOTA (B).