Table 1. Stability of 67Ga-Labeled Model Chelatorsa.
| murine
plasma |
ApoTf (0.1 mM) |
|||
|---|---|---|---|---|
| 3 h | 24 h | 3 h | 24 h | |
| [67Ga]Ga-p-NO2-Bn-DOTA (A) | 97.6 ± 0.3cdef | 95.9 ± 0.1cdef | 95.1 ± 1.2def | 90.3 ± 0.7cdef |
| [67Ga]Ga-p-NO2-Bn-DOTA (B) | 96.2 ± 0.4b | 85.9 ± 0.4bcde | 89.5 ± 0.7bcde | 56.0 ± 0.5bcde |
| [67Ga]Ga-DOTAGAMBu | 96.1 ± 0.4b | 82.2 ± 0.2bcd | 80.0 ± 1.3bcd | 27.5 ± 4.6bcd |
| [67Ga]Ga-DO3AMBu | 96.1 ± 0.6b | 83.9 ± 0.5bc | 87.4 ± 0.5bc | 43.1 ± 1.1bc |
| [67Ga]Ga-p-NO2-Bn-DO3A | 96.7 ± 0.5 | 87.6 ± 0.3b | 93.8 ± 0.6b | 67.5 ± 0.6b |
| [67Ga]Ga-DOTA | 97.5 ± 0.5 | 95.5 ± 0.4 | 96.4 ± 0.2 | 89.6 ± 0.5 |
Results are expressed as mean ± SD (n = 5).
Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with [67Ga]Ga-DOTA.
Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-p-NO2-Bn-DO3A.
Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-DO3AMBu.
Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-DOTAGAMBu.
Significances determined by Tukey’s test for the one-way ANOVA; p < 0.05 compared with[67Ga]Ga-p-NO2-Bn-DOTA (B).