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. Author manuscript; available in PMC: 2023 Sep 24.
Published in final edited form as: Toxicol Sci. 2022 Sep 24;189(2):155–174. doi: 10.1093/toxsci/kfac084

Table 1.

Default Values for Model Parameters Describing Proportion of the Maternal Body and Breast Milk That Are Lipid (Denoted Fm and Fmilk, Respectively) and the Ratio of Concentrations in Fetus(es) and Mother During Pregnancy (Denoted Rfm) in Various Species

Quantity Rat Mouse Human
F m 0.094a 0.229b 0.346c
F milk 0.154d 0.264e 0.039f
R fm 0.35 0.35 0.5
a

Neto Angéloco et al. (2012, Table 3). The value given here is the mean value for a control group of Wistar rats given a “standard AIN-93 diet.”

b

Reed et al. (2007, Section 2.4). The value given here is the overall mean for female mice from 40 strains.

c

Borrud et al. (2010, Table 3). The value given here is a weighted average of the mean values listed for females of “all races and ethnicities” for the age categories 8–11, 12–15, 16–19, and 20–39 years. Means for these age categories were converted to a weighted average by multiplying each mean by the sample size for the corresponding age category and then dividing by the sum of the sample sizes.

d

Nicholas and Hartmann (1991, Table 2). The value given here is the average of the mean values listed for all 5 time points and for both diets.

e

Johnson et al. (2001). The value given here is the average for milk from 10 female mice (MF1) on day 15 of lactation.

f

Arcus-Arth et al. (2005, Table 2). The value given here is the mean value for “all measurement periods” (through 12 months post-partum).