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. Author manuscript; available in PMC: 2023 Sep 24.
Published in final edited form as: Toxicol Sci. 2022 Sep 24;189(2):155–174. doi: 10.1093/toxsci/kfac084

Table 2.

Default Values for Model Parameters Describing Animal Body Masses

Quantity (Units) Rat Mouse
tm1 (day) 1 1
Mm1 (kg) 0.25a 0.0255b
tm2 (day) 44 25
Mm2 (kg) 0.273c 0.0318b
ti1 (day) 3 1
Mi1 (kg) 0.0066c 0.0014d
ti2 (day) 10 10
Mi2 (kg) 0.014c 0.00608e
ti3 (day) 17 18
Mi3 (kg) 0.028c 0.00885f
ti4 (day) 75g 45g
Mi4 (kg) 0.25a 0.03h
a

U.S. EPA (1988b, Table 4-2). The value listed is the “reference body weight” for rats.

b

Al Jothery et al. (2014, text and Table 2). The values listed for 1 and 25 days are the average mass values for rat dams at baseline (from the first paragraph of the Results section) and during lactation (from Table 2), respectively.

c

Lehmann et al. (2014, Table 3). The second mass value listed for a rat dam is the “dam weight during lactation” and the pup masses are those for “week 1,” “week 2,” and “week 3.”

d

U.S. EPA (1988a, Table 3-3). The mouse pup mass value listed for 1 day is the average of the B6C3F1 male and female “Weight at Birth” values.

e

Al Jothery et al. (2014, Figure 5B). The mouse pup value listed for 10 days is the average of the values for 2 data points (one each for high and low food intake lines) depicted in the figure. Coordinates of the points were digitally extracted using WebPlotDigitizer (Rohatgi, 2021).

f

Al Jothery et al. (2014, Table 1). The mouse mass listed for 18 days is the average of the mean “pup mass at weaning” values for 2 lines of mice selected for high and low food intake.

g

U.S. EPA (2002, Table 3-1). The time values listed for the rat and the mouse correspond to the ages of sexual maturity (2.5 months and 1.5 months, respectively) in those species.

h

U.S. EPA (1988a, Section 3.2.1). The value listed is the reference value for an adult mouse.