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. 2022 Dec 1;19:284. doi: 10.1186/s12974-022-02647-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — HsTx2 alleviates IL-1β-induced astrocyte inflammation via the circ_0001293/miR-8114/TGF-β2 axis. a RT–qPCR was used to determine the expression of circ_0001293, miR-8114 and TGF-β2. b Cell viability was detected using the CCK-8 assay. c ELISAs were conducted to determine the levels of TNF-α, IFN-γ, IL-6, IL-10 and TGF-β2. d Levels of MAPK- and NF-κB-related proteins were determined using Western blotting. ^***P < 0.001 compared with NC; ^###P < 0.001 compared with IL-1β; ^&P < 0.05, ^&&P < 0.01 and ^&&&P < 0.001 compared with IL-1β + HsTx2. All values are presented as the means ± SD (n = 3)