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. 2022 Dec 1;23:789. doi: 10.1186/s12864-022-09044-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Biomarkers screening based on machine learning classifier. A Meandecrease accuracy of 10 candidate biomarkers in random forest analysis. B Mean decrease gini of 10 candidate biomarkers in random forest analysis. C Predictive performances of the 10 biomarkers. D ROC curve for prediction with the combined biomarkers. E ROC curve for prediction with NT-proBNP. F Relative concentrations of 10 biomarkers selected by random forest and concentration of NT-proBNP