Table 2.
Association of ovarian volume and morphology with hormonal parameters
| Variables | Testosterone | FAI | LH/FSH | HOMA-IR | ||||
|---|---|---|---|---|---|---|---|---|
| β (SE) | P value | β (SE) | P value | β (SE) | P value | β (SE) | P value | |
| PCOM (bilateral vs. unilateral) | ||||||||
| Model 1 (unadjusted) | 0.098 (0.051) | 0.060 | 0.285 (0.099) | 0.006 | -0.162 (0.090) | 0.079 | -0.025 (0.052) | 0.629 |
| Model 2 | 0.104 (0.051) | 0.044 | 0.289 (0.100) | 0.005 | -0.160 (0.091) | 0.086 | -0.028 (0.052) | 0.597 |
| Model 3 | 0.116 (0.052) | 0.028 | 0.252 (0.101) | 0.015 | -0.166 (0.094) | 0.084 | -0.044 (0.053) | 0.402 |
| Model 4 | 0.119 (0.052) | 0.028 | 0.216 (0.096) | 0.029 | -0.153 (0.095) | 0.113 | -0.068 (0.048) | 0.164 |
| Right OV (cm3) | ||||||||
| Model 1 (unadjusted) | 0.020 (0.005) | < 0.001 | 0.037 (0.010) | 0.001 | 0.027 (0.009) | 0.006 | 0.001 (0.006) | 0.945 |
| Model 2 | 0.020 (0.005) | < 0.001 | 0.037 (0.010) | 0.001 | 0.027 (0.009) | 0.007 | 0.001 (0.006) | 0.935 |
| Model 3 | 0.020 (0.005) | < 0.001 | 0.038 (0.010) | < 0.001 | 0.027 (0.010) | 0.008 | 0.001 (0.006) | 0.899 |
| Model 4 | 0.021 (0.005) | < 0.001 | 0.033 (0.010) | 0.001 | 0.030 (0.009) | 0.002 | -0.003 (0.005) | 0.573 |
| Left OV (cm3) | ||||||||
| Model 1 (unadjusted) | 0.021 (0.006) | 0.001 | 0.041 (0.011) | < 0.001 | 0.015 (0.011) | 0.166 | 0.001 (0.006) | 0.952 |
| Model 2 | 0.020 (0.006) | 0.001 | 0.040 (0.011) | 0.001 | 0.014 (0.011) | 0.192 | 0.001 (0.006) | 0.959 |
| Model 3 | 0.020 (0.006) | 0.002 | 0.044 (0.011) | < 0.001 | 0.016 (0.011) | 0.152 | 0.001 (0.006) | 0.892 |
| Model 4 | 0.024 (0.006) | 0.001 | 0.037 (0.012) | 0.003 | 0.024 (0.012) | 0.047 | -0.007 (0.006) | 0.243 |
| aRight + Left OV (cm3) | ||||||||
| Model 1 (unadjusted) | 0.022 (0.005) | < 0.001 | 0.045 (0.011) | < 0.001 | 0.025 (0.010) | 0.017 | 0.001 (0.006) | 0.947 |
| Model 2 | 0.022 (0.005) | < 0.001 | 0.045 (0.011) | < 0.001 | 0.025 (0.010) | 0.018 | 0.001 (0.006) | 0.955 |
| Model 3 | 0.022 (0.005) | < 0.001 | 0.047 (0.010) | < 0.001 | 0.025 (0.010) | 0.019 | 0.001 (0.006) | 0.964 |
| Model 4 | 0.025 (0.006) | < 0.001 | 0.041 (0.011) | < 0.001 | 0.032 (0.011) | 0.004 | -0.006 (0.006) | 0.288 |
| bAFC | ||||||||
| Model 1 (unadjusted) | 0.001 (0.001) | 0.204 | 0.003 (0.002) | 0.048 | -0.001 (0.002) | 0.669 | 0.002 (0.001) | 0.046 |
| Model 2 | 0.001 (0.001) | 0.186 | 0.003 (0.002) | 0.051 | -0.001 (0.002) | 0.685 | 0.002 (0.001) | 0.049 |
| Model 3 | 0.001 (0.001) | 0.119 | 0.003 (0.002) | 0.110 | -0.001 (0.002) | 0.658 | 0.001 (0.001) | 0.103 |
| Model 4 | 0.001 (0.001) | 0.122 | 0.001 (0.002) | 0.383 | 0.001 (0.002) | 0.858 | 0.001 (0.001) | 0.346 |
| a2-5 mm FNPO | ||||||||
| Model 1 (unadjusted) | 0.002 (0.002) | 0.389 | 0.006 (0.004) | 0.151 | 0.004 (0.004) | 0.303 | 0.004 (0.002) | 0.029 |
| Model 2 | 0.001 (0.002) | 0.529 | 0.006 (0.004) | 0.175 | 0.003 (0.004) | 0.417 | 0.004 (0.002) | 0.020 |
| Model 3 | 0.002 (0.002) | 0.393 | 0.006 (0.004) | 0.183 | 0.003 (0.004) | 0.453 | 0.004 (0.002) | 0.030 |
| Model 4 | 0.002 (0.002) | 0.417 | 0.003 (0.004) | 0.487 | 0.004 (0.004) | 0.317 | 0.003 (0.002) | 0.088 |
| a6-9 mm FNPO | ||||||||
| Model 1 (unadjusted) | 0.003 (0.007) | 0.678 | -0.008 (0.014) | 0.564 | 0.001 (0.013) | 0.989 | 0.002 (0.007) | 0.751 |
| Model 2 | 0.006 (0.007) | 0.380 | -0.007 (0.014) | 0.613 | 0.004 (0.013) | 0.788 | 0.001 (0.007) | 0.851 |
| Model 3 | 0.007 (0.007) | 0.379 | -0.007 (0.014) | 0.596 | 0.004 (0.013) | 0.788 | 0.001 (0.007) | 0.862 |
| Model 4 | 0.007 (0.007) | 0.378 | -0.006 (0.012) | 0.603 | 0.003 (0.013) | 0.803 | 0.002 (0.006) | 0.807 |
| a2-9 mm FNPO | ||||||||
| Model 1 (unadjusted) | 0.001 (0.001) | 0.331 | 0.003 (0.003) | 0.299 | 0.003 (0.003) | 0.276 | 0.003 (0.001) | 0.021 |
| Model 2 | 0.002 (0.001) | 0.283 | 0.003 (0.003) | 0.309 | 0.003 (0.003) | 0.260 | 0.003 (0.001) | 0.024 |
| Model 3 | 0.002 (0.001) | 0.226 | 0.002 (0.003) | 0.440 | 0.003 (0.003) | 0.267 | 0.003 (0.001) | 0.041 |
| Model 4 | 0.002 (0.002) | 0.233 | 0.001 (0.003) | 0.899 | 0.004 (0.003) | 0.142 | 0.002 (0.001) | 0.184 |
| aOvarian area (cm2) | ||||||||
| Model 1 (unadjusted) | 0.017 (0.014) | 0.240 | 0.031 (0.027) | 0.248 | 0.029 (0.024) | 0.245 | 0.014 (0.013) | 0.276 |
| Model 2 | 0.014 (0.014) | 0.321 | 0.030 (0.027) | 0.269 | 0.028 (0.025) | 0.270 | 0.014 (0.013) | 0.289 |
| Model 3 | 0.014 (0.014) | 0.345 | 0.032 (0.027) | 0.236 | 0.028 (0.025) | 0.268 | 0.015 (0.013) | 0.250 |
| Model 4 | 0.013 (0.014) | 0.364 | 0.027(0.025) | 0.227 | 0.029 (0.025) | 0.259 | 0.013 (0.012) | 0.305 |
| aStromal area (cm2) | ||||||||
| Model 1 (unadjusted) | 0.009 (0.013) | 0.502 | 0.031 (0.025) | 0.214 | 0.008 (0.023) | 0.726 | 0.013 (0.012) | 0.275 |
| Model 2 | 0.007 (0.013) | 0.607 | 0.032 (0.025) | 0.204 | 0.007 (0.024) | 0.777 | 0.014 (0.012) | 0.251 |
| Model 3 | 0.007 (0.013) | 0.578 | 0.030 (0.025) | 0.229 | 0.007 (0.024) | 0.784 | 0.013 (0.012) | 0.280 |
| Model 4 | 0.007 (0.013) | 0.572 | 0.035 (0.022) | 0.121 | 0.005 (0.024) | 0.835 | 0.016 (0.011) | 0.165 |
| aS/A | ||||||||
| Model 1 (unadjusted) | 0.005 (0.190) | 0.978 | -0.102 (0.354) | 0.775 | 0.169 (0.322) | 0.602 | 0.085 (0.174) | 0.629 |
| Model 2 | -0.021 (0.188) | 0.912 | -0.114 (0.359) | 0.752 | 0.158 (0.326) | 0.631 | 0.082 (0.176) | 0.643 |
| Model 3 | -0.011 (0.188) | 0.955 | -0.140 (0.356) | 0.697 | 0.153 (0.330) | 0.646 | 0.069 (0.174) | 0.694 |
| Model 4 | 0.005 (0.195) | 0.978 | 0.083 (0.337) | 0.806 | 0.131 (0.343) | 0.703 | 0.184 (0.163) | 0.264 |
AFC antral follicle count, FAI free androgen index, FNPO follicle number per ovary, FSH follicle-stimulating hormone, HOMA-IR homeostasis model assessment of insulin resistance, LH luteinizing hormone, OV ovarian volume, PCOM polycystic ovarian morphology, S/A stromal to ovarian area ratio
Model 2 includes variables from model 1 plus age; Model 3 includes variables from model 1 plus age and mensuration status; Model 4 includes variables from model 1 plus age, mensuration status and BMI
aThe mean value of the left and right ovary was used for analysis
bSum of follicles in both ovaries